The direct antiglobulin (Coombs) test in megaloblastic anaemia

The Direct Antiglobulin (coombs) Test in Megaloblastic Anaemia.

Folic acid deficiency with the picture of a megaloblastic bone marrow may develop in haemolytic anaemia, and, on the other hand, both vitamin B(12) and folic acid deficiency may produce signs of haemolysis. As the correct interpretation of a positive antiglobulin reaction associated with megaloblastic erythropoiesis is particularly important, the effect of deficiency of vitamin B(12) and folic ...

Direct antiglobulin ("Coombs") test-negative autoimmune hemolytic anemia: a review.

We have reviewed the literature to identify and characterize reports of warm-antibody type, autoimmune hemolytic anemia in which the standard direct antiglobulin reaction was negative but a confirmatory test indicated that the red cells were opsonized with antibody. Three principal reasons account for the absence of a positive direct antiglobulin test in these cases: a) IgG sensitization below ...

Coombs’ Direct Antiglobulin Test Among Individuals Co-Infected with Malaria and HIV in Iwo Community, Southwestern Nigeria

In the present study, direct antiglobulin test (DAT) was performed using poly-antiglobulin serum on a total of 138 individuals; 20 of whom had HIV infection only, 50 malaria only, 18 both malaria and HIV and 50 non-infected with either malaria or HIV in order to determine the effect of co-infection with malaria and HIV on DAT status. Malaria parasite test was done by microscopic examination of ...

Positive direct Coombs test induced by phenylhydrazine.

Megaloblastic Anaemia in Haemochromatosis.

IN 1877 Muller described a marked bronzed discoloration of the skin in some patients considered to have pernicious anaemia. This observation, confirmed later by Immerman (1879) is likely to be the first record of an association between a macrocytic type of anemia and haemochromatosis. Since that time French (1909), Roth (1915), Bork (1928), Cain (1940), Hotz (1944) and Harvier and Mallarme (193...